C22

Malignant neoplasm of liver and intrahepatic bile ducts

Header / non-billable

This code does not map to a risk-adjusting HCC in the loaded models.

Coding notes

Excludes 1 never coded together · Excludes 2 may co-exist

This code · C22
Excludes 1

malignant neoplasm of biliary tract NOS (C24.9) secondary malignant neoplasm of liver and intrahepatic bile duct (C78.7)

Use additional

code to identify: alcohol abuse and dependence (F10.-) hepatitis B (B16.-, B18.0-B18.1) hepatitis C (B17.1-, B18.2)

Inherited from C15-C26Malignant neoplasms of digestive organs
Excludes 1

Kaposi's sarcoma of gastrointestinal sites (C46.4)

Excludes 2

gastrointestinal stromal tumors (C49.A-)

Inherited from chapter 2Neoplasms
Note

Functional activity All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm. Morphology [Histology] Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes. Primary malignant neoplasms overlapping site boundaries A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned. Malignant neoplasm of ectopic tissue Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9). (C00-C96) Malignant neoplasms (C00-C96) (C00-C75) Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue (C00-C75)

Official Guidelines for C22

FY 2026 ›