D57.4

Sickle-cell thalassemia

Header / non-billable

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This code does not map to a risk-adjusting HCC in the loaded models.

Coding notes

Excludes 1 never coded together · Excludes 2 may co-exist

This code · D57.4

Synonyms

Sickle-cell beta thalassemia Thalassemia Hb-S disease

Inherited from D57Sickle-cell disorders

Excludes 1

other hemoglobinopathies (D58.-)

Use additional

code for any associated fever (R50.81)

Inherited from chapter 3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Excludes 2

autoimmune disease (systemic) NOS (M35.9) certain conditions originating in the perinatal period (P00-P96) complications of pregnancy, childbirth and the puerperium (O00-O9A) congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) endocrine, nutritional and metabolic diseases (E00-E88) human immunodeficiency virus [HIV] disease (B20) injury, poisoning and certain other consequences of external causes (S00-T88) neoplasms (C00-D49) symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Official Guidelines for D57.4

FY 2026 ›

I.C.3Chapter-specific guidanceChapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)