D89.3

Immune reconstitution syndrome

Risk-adjusting (HCC)Billable code

HCC risk adjustment mapping

CMS-HCC ESRD V24

HCC47

Disorders of Immunity

RxHCC V08

RXHCC99

Immune Disorders

Coding notes

Excludes 1 never coded together · Excludes 2 may co-exist

This code · D89.3
Use additional

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Synonyms

Immune reconstitution inflammatory syndrome [IRIS]

Inherited from D89Oth disorders involving the immune mechanism, NEC
Excludes 1

hyperglobulinemia NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes 2

transplant failure and rejection (T86.-)

Inherited from D80-D89Certain disorders involving the immune mechanism
Includes

defects in the complement system immunodeficiency disorders, except human immunodeficiency virus [HIV] disease sarcoidosis

Excludes 1

autoimmune disease (systemic) NOS (M35.9) functional disorders of polymorphonuclear neutrophils (D71-) human immunodeficiency virus [HIV] disease (B20)

Inherited from chapter 3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Excludes 2

autoimmune disease (systemic) NOS (M35.9) certain conditions originating in the perinatal period (P00-P96) complications of pregnancy, childbirth and the puerperium (O00-O9A) congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) endocrine, nutritional and metabolic diseases (E00-E88) human immunodeficiency virus [HIV] disease (B20) injury, poisoning and certain other consequences of external causes (S00-T88) neoplasms (C00-D49) symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Official Guidelines for D89.3

FY 2026 ›
I.C.3Chapter-specific guidanceChapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

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