E34.321

Primary insulin-like growth factor-1 (IGF-1) deficiency

Billable code

This code does not map to a risk-adjusting HCC in the loaded models.

Coding notes

Excludes 1 never coded together · Excludes 2 may co-exist

This code · E34.321
Synonyms

Acid-labile subunit gene (IGFALS) defect Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies Growth hormone insensitivity syndrome (GHIS) Insulin-like growth factor 1 gene (IGF1) defect Laron type short stature Severe primary insulin-like growth factor-1 deficiency (SPIGFD) Signal transducer and activator of transcription 5B gene (STAT5b) defect

Inherited from E34.3Short stature due to endocrine disorder
Excludes 1

achondroplastic short stature (Q77.4) hypochondroplastic short stature (Q77.4) nutritional short stature (E45) pituitary short stature (E23.0) progeria (E34.8) renal short stature (N25.0) Russell-Silver syndrome (Q87.19) short-limbed stature with immunodeficiency (D82.2) short stature (child) (R62.52) short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index short stature NOS (R62.52)

Inherited from E34Other endocrine disorders
Excludes 1

pseudohypoparathyroidism (E20.1)

Inherited from E20-E35Disorders of other endocrine glands
Excludes 1

galactorrhea (N64.3) gynecomastia (N62)

Inherited from chapter 4Endocrine, nutritional and metabolic diseases
Excludes 1

transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Note

All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Official Guidelines for E34.321

FY 2026 ›