D68.51

Activated protein C resistance

Risk-adjusting (HCC)Billable code

HCC risk adjustment mapping

CMS-HCC ESRD V24

HCC48

Coagulation Defects and Other Specified Hematological Disorders

Coding notes

Excludes 1 never coded together · Excludes 2 may co-exist

This code · D68.51
Synonyms

Factor V Leiden mutation

Inherited from D68.5Primary thrombophilia
Excludes 1

antiphospholipid syndrome (D68.61) lupus anticoagulant (D68.62) secondary activated protein C resistance (D68.69) secondary antiphospholipid antibody syndrome (D68.69) secondary lupus anticoagulant with hypercoagulable state (D68.69) secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69) systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0) systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312) thrombotic thrombocytopenic purpura (M31.19)

Synonyms

Primary hypercoagulable states

Inherited from D68Other coagulation defects
Excludes 1

abnormal coagulation profile NOS (R79.1)

Excludes 2

coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1) coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)

Inherited from chapter 3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Excludes 2

autoimmune disease (systemic) NOS (M35.9) certain conditions originating in the perinatal period (P00-P96) complications of pregnancy, childbirth and the puerperium (O00-O9A) congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) endocrine, nutritional and metabolic diseases (E00-E88) human immunodeficiency virus [HIV] disease (B20) injury, poisoning and certain other consequences of external causes (S00-T88) neoplasms (C00-D49) symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Official Guidelines for D68.51

FY 2026 ›