D56.0

Alpha thalassemia

Risk-adjusting (HCC)Billable code

HCC risk adjustment mapping

CMS-HCC ESRD V24

HCC48

Coagulation Defects and Other Specified Hematological Disorders

Coding notes

Excludes 1 never coded together · Excludes 2 may co-exist

This code · D56.0
Excludes 1

alpha thalassemia trait or minor (D56.3) asymptomatic alpha thalassemia (D56.3) hydrops fetalis due to isoimmunization (P56.0) hydrops fetalis not due to immune hemolysis (P83.2)

Use additional

code, if applicable, for hydrops fetalis due to alpha thalassemia (P56.99)

Synonyms

Alpha thalassemia major Hemoglobin H Constant Spring Hemoglobin H disease Hydrops fetalis due to alpha thalassemia Severe alpha thalassemia Triple gene defect alpha thalassemia

Inherited from D56Thalassemia
Excludes 1

sickle-cell thalassemia (D57.4-)

Inherited from chapter 3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Excludes 2

autoimmune disease (systemic) NOS (M35.9) certain conditions originating in the perinatal period (P00-P96) complications of pregnancy, childbirth and the puerperium (O00-O9A) congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) endocrine, nutritional and metabolic diseases (E00-E88) human immunodeficiency virus [HIV] disease (B20) injury, poisoning and certain other consequences of external causes (S00-T88) neoplasms (C00-D49) symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Official Guidelines for D56.0

FY 2026 ›