D56.5

Hemoglobin E-beta thalassemia

Risk-adjusting (HCC)Billable code

HCC risk adjustment mapping

CMS-HCC V28

HCC108

Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major

CMS-HCC ESRD V24

HCC48

Coagulation Defects and Other Specified Hematological Disorders

Coding notes

Excludes 1 never coded together · Excludes 2 may co-exist

This code · D56.5

Excludes 1

beta thalassemia (D56.1) beta thalassemia minor (D56.3) beta thalassemia trait (D56.3) delta-beta thalassemia (D56.2) delta-beta thalassemia trait (D56.3) hemoglobin E disease (D58.2) other hemoglobinopathies (D58.2) sickle-cell beta thalassemia (D57.4-)

Inherited from D56Thalassemia

Excludes 1

sickle-cell thalassemia (D57.4-)

Inherited from chapter 3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Excludes 2

autoimmune disease (systemic) NOS (M35.9) certain conditions originating in the perinatal period (P00-P96) complications of pregnancy, childbirth and the puerperium (O00-O9A) congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) endocrine, nutritional and metabolic diseases (E00-E88) human immunodeficiency virus [HIV] disease (B20) injury, poisoning and certain other consequences of external causes (S00-T88) neoplasms (C00-D49) symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Official Guidelines for D56.5

FY 2026 ›

I.C.3Chapter-specific guidanceChapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

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